How many times can you take Pralsetinib a year and how much does it cost?

Pralsetinib (Pralsetinib) is an oral, selective RET kinase inhibitor indicated for the treatment of rearrangement during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC) and RET-mutant medullary thyroid carcinoma (MTC). Platinib can only be used if a patient's cancer has a specific genetic marker (an abnormal "RET" gene fusion). Doctors will perform gene fusion tests onpatients. The U.S. Food and Drug Administration (FDA) approved platinib on an “accelerated” basis. In clinical studies, some people responded to platinib, but further study is needed. The conventional adult dose of platinib is 400 mg orally once daily, and the treatment duration is until disease progression or unacceptable toxicity. It is estimated that it can be taken more than 300 times a year, provided that the patient does not need to adjust the dose due to adverse reactions.

The original drug Platinib has been launched in China, but it has not yet passed the relevant policies to be included in the medical insurance. The specification is 100mg and the price of 120 pills per box may be around 60,000 yuan. According to its prescription information, patients need about 3 boxes for one year, which may be as high as hundreds of thousands of RMB. The European version of Platinib's original drug sold overseas may cost around 40,000 RMB per box of 60 pills, and the US version may cost around 150,000 RMB per box (the price may fluctuate due to exchange rates), which is expensive. Generic drugs of Platinib are also available for sale overseas. The ingredients of the drug are basically the same as those of the original drug at home and abroad. The price of 120 pills per box may be more than 4,000 RMB (the price may fluctuate due to the exchange rate), and the cost may be tens of thousands of RMB.