How effective is Eltrombopag?

Eltrombopag is a platelet-raising drug used to treat patients with chronic immune thrombocytopenia (ITP), chronic hepatitis C-related thrombocytopenia, and severe aplastic anemia.

In a Phase 2/3 trial, patients with chronic /persistent immune thrombocytopenia (ITP) experienced increased platelet counts and reduced bleeding after 6 months or less of treatment with eltrombopag.

This open-label extension study evaluated the long-term safety and efficacy of eltrombopag in adultITP patients who had previously completed studies of eltrombopag. Among the 302 patients enrolled, the average duration of eltrombopag treatment was 2.37 years (2 days - 8.76 years). The median platelet count increased to 50 × 109/L or more and was sustained throughout treatment. Overall, 259patients(85.8%)achieved remission(platelet count≥50 × 109/Lat least once, 257patients 133(52%)achieved a sustained response for 25 weeks or longer with a platelet count below 15. × Responses in 109/L, more prior treatment, and / or splenectomy were slightly lower in 101 patients who received combined34 (34%) of patients on ITP medications discontinued 1 or more medications. Among patients evaluated, bleeding symptoms(World Health Organization1-4Level )from baseline 57% at 1 dropped to 16% at 1. 41patients(14%)withdrawn due to adverse events. More than 1 patient experienced hepatobiliary adverse events(n = 7), cataract(n = 4), deep vein thrombosis(n = 3), cerebral infarction(n = 2), headache(n = 2)and myelofibrosis(n = 2); the remaining adverse events occurred only once. The incidence of thromboembolic events (6%) and hepatobiliary adverse events (15%) did not increase with treatment duration beyond 1 year. EXTENDProven that long-term use of eltrombopag can effectively maintain 50 × A platelet count of 109/L or higher and reduced bleeding in most patients with ITP lasting longer than 6 months. Important adverse events(such as thrombosis, hepatobiliary and myelofibrosis)occur rarely. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.

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