Latest price situation: How much does it cost to import Avonib?

Ivosidenib (Ivosidenib), branded as Tibsovo, is an anti-cancer drug used to treat acute myeloid leukemia (AML) and cholangiocarcinoma. It is a small molecule inhibitor of isocitrate dehydrogenase-1 (IDH1), which is mutated in several cancers. Ivonib is an isocitrate dehydrogenase 1 inhibitor that works by reducing the abnormal production of the tumor metabolite 2-hydroxyglutarate (2-HG), which leads to the differentiation of malignant cells.

Avosidenib was approved for medical use in the United States in July 2018 and in in the European Union in May 2023. The U.S. Food and Drug Administration (FDA) considers it a first-in-class drug. Adverse reactions reported in patients receiving ivonib include febrile neutropenia, increased alanine aminotransferase, increased aspartate aminotransferase, colitis, hypertension, and maculopapular rash. However, ivonib is taken along with standard AML induction therapy, and the side effects cannot be directly related to the drug.

IvonibThe original drug is already on the domestic market and is an imported drug, but it is not included in the scope of medical insurance. The price of domestically sold specifications0.25g*60 tablets per box is as high as 100,000 yuan, while the price of the American original version sold overseas is as high as more than 200,000 yuan per box (the price may fluctuate due to exchange rates). Generic drugs of Ivonib are also sold overseas. Their drug ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 250mg*60 tablets produced by a Laos pharmaceutical factory may be more than 6,000 yuan per box (the price may fluctuate due to the exchange rate), and the price is relatively cheap.