What are the precautions when taking tucatinib/tucatinib?

Tucatinib/Tucatinib is a kinase inhibitor drug used with trastuzumab and capecitabine for the treatment of unresectable or metastatic HER-2-positive breast cancer. It was developed by Seattle Genetics and was approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer who have responded poorly to other chemotherapy regimens.

1.Diarrhea. Tucatinibcan cause severe diarrhea, including dehydration, hypotension, acute kidney injury, and death. If diarrhea occurs, treat with antidiarrheal medications as clinically indicated. Diagnostic testing is performed as clinically indicated to rule out other causes of diarrhea. Depending on the severity of diarrhea, interrupt dose, then reduce dose or permanently discontinue tucatinib.

2.Hepatotoxicity

Tucatinibcan cause severe hepatotoxicity. Monitor ALT, AST and bilirubin before initiatingtucatinib, every 3 weeks during treatment, and as clinically indicated. Depending on the severity of hepatotoxicity, interrupt dose and then reduce dose or permanently discontinue tucatinib.

3.Embryo-Fetal Toxicity. Based on the results of animal studies and its mechanism of action, taking tucatinib by pregnant women may cause harm to the fetus. In animal reproduction studies, administration of tucatinib to pregnant rats and rabbits during organogenesis resulted in fetal death, reduced fetal weight, and fetal malformations (maternal exposure ≥ 1.3 times the recommended human exposure (AUC)). Inform pregnant women and women of reproductive potential of the potential risk to the fetus and advise women of childbearing potential to use effective contraception during treatment with tucatinib and for 1 weeks after the last dose. Recommended for male patients who have a female partner of childbearing potentialUse effective contraception during tucatinib treatment and for 1 week after the last dose. There is a generic version of this medicine in Bangladesh. The retail price of Everest Pharmaceuticals in Bangladesh is about 30 tablets of 150mg6000 yuan. The retail price of Ziska Pharmaceuticals in Bangladesh is around 4,500 yuan for 150 mg 30 tablets. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to help you learn more about high-quality overseas drugs.

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