How many courses of treatment does venetoclax/venetoclax plus azacitidine require and how much does it cost?

Venetoclax plus azacitidine is a regimen used to treat acute myeloid leukemia (AML) and has a high relapse rate and a high survival rate. The specific number of treatments is usually determined by the doctor based on the patient's condition and treatment effects.

Recommended doses and increments of venetoclax depend on the combination, following a dosing schedule that includes3-day or 4-day dose escalation, starting with an oral dose of 100 mg on Day 1 of Cycle 1, followed by an oral dose of 200 mg on Day 3 The daily oral dose is 400 mg on day 4 and thereafter. At this time, 75 mg/m2 of azacitidine can be injected intravenously or subcutaneously once a day on days 1 to 7 of each 28-day cycle. Generally speaking, multiple courses of treatment with venetoclax plus azacitidine are usually required to achieve optimal efficacy. The exact number and intervals of each treatment session may vary based on individual patient differences.

The original drug of Venekra has been launched in China and has been included in Class B medical insurance. The price of 100mg*14 tablets per box may be around 2,000 RMB, while the Turkish version of the original drug sold overseas, with the specification of 100mg*112 tablets, costs more than 10,000 RMB per box (the price may fluctuate due to the exchange rate). There are also cheaper generic drugs of Venacla sold overseas. Their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 100mg*120 tablets produced by a Bangladesh pharmaceutical factory is more than 4,000 yuan per box (the price may fluctuate due to the exchange rate).