Miraculous medicine to get rid of diseases: efficacy and effects of venetoclax/venetoclax

Venetoclax is effective in both CLL (chronic lymphocytic leukemia) and acute myeloid leukemia (AML), with trials reporting that significantly more patients achieved complete remission using venetoclax in combination with other treatments compared with standard therapy. Venetoclax also works quickly, with many people taking an average of a month to feel a slowdown in disease progression.

In a trial comparing venetuzumab plus venetuzumabObinutuzumab (V+O) with obinutuzumab plus chlorambucil (O+C), after a mean of 28 monthstreatment, the overall response rate was 85%, with 46% of patients experiencing a complete response, the mean time to response was 0.8 months (range, 0.1 to 8.1 months), which was an average of 24 days, and the duration of response ranged from 2.4 months to 52.4 months. The trial also investigated the efficacy of venetoclax in AML patients aged 75 and older who were unable to receive intensive induction chemotherapy for one of the following reasons. When venetoclax was combined with low-dose cytarabine, 21% of patients experienced clinical remission. The median observed time to response was 6.0 months.

The original drug of Venekra has been launched in China and has been included in Class B medical insurance. The price of 100mg*14 tablets per box may be around 2,000 RMB, while the Turkish version of the original drug sold overseas, with the specification of 100mg*112 tablets, costs more than 10,000 RMB per box (the price may fluctuate due to the exchange rate). There are also cheaper generic drugs of Venacla sold overseas. Their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 100mg*120 tablets produced by a Bangladesh pharmaceutical factory is more than 4,000 yuan per box (the price may fluctuate due to the exchange rate).