How much does entrectinib cost? How much does an individual pay after medical insurance reimbursement?

Entrectinib was approved by the FDA in August 2019 >Approved for the treatment of ROS1positive metastatic non-small cell lung cancer and NTRK gene fusion-positive solid tumors. Entrectinib(Entrectinib) was approved for marketing by China Food and Drug Administration in 2022 July . Currently, Entrectinib has been included in medical insurance and can be reimbursed. The retail price in domestic pharmacies is around 23,800 yuan for 200 mg of 90 tablets. After medical insurance is reimbursed, the individual will pay several thousand yuan. Each region and policy are different, and the reimbursement ratio is different. For specific costs, please consult the local medical insurance bureau.

The most serious adverse reactions of entrectinib are congestive heart failure, central nervous system effects, skeletal fractures, hepatotoxicity, hyperuricemia, QT prolongation, and visual impairment. The most common adverse reactions reported in at least 20% of patients were fatigue, constipation, dysgeusia, edema, dizziness, diarrhea, nausea, dysesthesia, dyspnea, myalgia, cognitive impairment, weight gain, cough, vomiting, pyrexia, arthralgia, and visual impairment.

Oral administration Entrectinibcapsules are printed hard-shell capsules containing 100mg (yellow opaqueHPMCcapsules) or 200mgentrectinib (orange opaqueHPMCcapsules). The inactive ingredients are tartaric acid, lactose anhydrous, hypromellose, crospovidone, microcrystalline cellulose, colloidal silicon dioxide, and magnesium stearate. The yellow opaque capsule shell contains hypromellose, titanium dioxide, and yellow iron oxide. The orange opaque capsule shell contains hypromellose, titanium dioxide, and FD&Cyellow#6. Printing ink contains shellac, propylene glycol, concentrated ammonia solution and FD&CBlue#2aluminum lake. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.

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