Can venetoclax/venetoclax be used long-term?

Venetoclax (Venetoclax) is a drug used to treat certain types of leukemia. Its use and duration should be determined by the doctor based on the patient's specific situation. In some cases, venetoclax may need to be used long-term to help control the progression of the disease. However, long-term use of venetoclax may also increase resistance to the drug, resulting in less effective treatment.

The mechanism of action of venetoclax is to directly bind to BCL-2 protein. When venetoclax binds to BCL-2, it displaces other proteins, such as BIM, which helps activate the apoptotic process, leading to programmed cell death. Cancer cells such as CLL, SLL and AML overexpress BCL-2, which means they have more BCL-2 than normal cells. By blocking or inhibiting BCL-2, venetoclax can kill these cells. Although venetoclax may help treat cancer, it is not a chemotherapy drug. Venexaclais a tablet that can be taken for 12 months or about 24 months, depending on other cancer treatments it is used with.

The original drug of Venekra has been launched in China and has been included in Class B medical insurance. The price of 100mg*14 tablets per box may be around 2,000 RMB, while the Turkish version of the original drug sold overseas, with the specification of 100mg*112 tablets, costs more than 10,000 RMB per box (the price may fluctuate due to the exchange rate). There are also cheaper generic drugs of Venacla sold overseas. Their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 100mg*120 tablets produced by a Bangladesh pharmaceutical factory is more than 4,000 yuan per box (the price may fluctuate due to the exchange rate).