Bangladesh Everest Pharmaceuticals sotoraxibu usage and dosage

Sotoracib (AMG510)is an anti-tumor drug for the treatment of locally advanced or metastatic diseaseKRAS G12C突变阳性(通过FDA批准的诊断试验检测)的非小细胞肺癌(NSCLC ), who had previously received ≥1 systemic therapy.在主要疗效研究中，局部晚期或转移性KRAS G12C突变非小细胞肺癌患者的客观缓解率为36%，这些患者之前接受过抗程序性死亡1 (PD-1)或抗程序性死亡配体1 (PD-L1)Monoclonal antibody, platinum-based combination chemotherapy, or both.

The recommended dose of sotorasiib is 960 mg once daily. Continuemedication until disease progression or unacceptable toxicity occurs.基于个体安全性和耐受性，可能有必要中断给药或减少索托拉西的剂量，如果需要从960 mg每日一次减少剂量，将剂量减少至480 mg每日一次，如果在480 If toxicity recurs at the mgonce daily dose, reduce the dose to 240 mgonce daily. If toxicity occurs at the 240 mg once daily dose, discontinue the drug.

Take at the same time every day, before and after meals . When taking, swallow the tablet whole, do not crush, chew or divide.或者对于不能吞咽整片药片的患者，将药片分散在120毫升的非碳酸室温水中，将该剂量的全部片剂(例如，总剂量为960 mg的8片120 mgTablets)Place in water, without crushing, and stir to disperse the tablets into small pieces(Complete dissolution will not occur),The color of the resulting mixture can range from pale yellow to bright yellow. Eat the entire mixture immediately or within 2 hours after mixing. Do not chew the remaining tablets. Rinse any residue left in the container with an additional 120 ml of water, stir again and drink immediately. The retail price of Bangladesh Everest Pharmaceuticals120mg56 tablets is priced from 4000 yuan to 5000 yuan. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.