Laos Element Pharmaceuticals sotolasibu monthly cost

Sotoraxib (AMG510) is an anti-tumor drug that has been launched in Laos. Sotoracib is indicated for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC). The retail price of pharmaceuticals in Laos is about RMB 15,600 per month. If patients need it, they can purchase it through regular domestic channels, and the quality of the medicines is guaranteed.

Sotoraxib blocksKRAS signaling, inhibits cell growth and promotes apoptosisKRAS G12C tumor cell line. The most common adverse reactions (≥ 20%) of sotorasiib were diarrhea, musculoskeletal pain, nausea, fatigue, hepatotoxicity, and cough. The most common laboratory abnormalities(≥ 25%)are lymphopenia, decreased hemoglobin, increased aspartate aminotransferase, increased alanine aminotransferase, decreased calcium, increased alkaline phosphatase, increased urinary protein, and decreased sodium.

The mean terminal elimination half-life of sotoraxib is 5 hours. At a dose of 960 mg once daily, the apparent clearance at steady state was 26.2 L/hr (CV: 76%). The main metabolic pathways of sotoraxib are non-enzymatic conjugation with CYP3As and oxidative metabolism. Sotoracibis aCYP3A4inducer. Combining sotoracibwithCYP3A4substrate can reduce its plasma concentration. Coadministration of sotorasiib withP-gp substrate may increase its plasma concentration. SotorasiibCoadministration with BCRP substrate may increase its plasma concentration. Laos Element PharmaceuticalsRetail price120mg56 tablets sell for more than 2 more than one thousand. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.

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