Correct usage and dosage of neratinib/neratinib, and how to use it?

Neratinib is a protein kinase inhibitor used to treat breast cancer that overexpresses the HER2 receptor. Neratinib was approved in July 2017 for the extended adjuvant treatment of human epidermal growth factor receptor 2 (HER 2)-positive breast cancer.

Premedication for Diarrhea:When dose escalation is not used, initiate loperamide with the first dose of neratiniband continue for the first 56 days of treatment. After the 56th day, loperamide was used to maintain 1-2 bowel movements per day. Long-term adjuvant treatment of early breast cancer: Take 240 mg (6tablets) orally once a day with food for one year until the disease recurs. Advanced or metastatic breast cancer:240 mg orally once daily with food on days 1-21 of cycle 21( pan>6tablets), and oral capecitabine (750 mg/m2 twice daily) on days 1-14 of the 21-day cycle until disease progression or unacceptable toxicity. Dose Escalation:A two-week dose escalation of neratinib may also be initiated. Dose interruptions and/or dose reductions are recommended based on individual safety and tolerability. Hepatic Impairment:Reduce starting dose to 80 mg in patients with severe hepatic impairment. Follow all directions on the prescription label, read all medication guides or inserts, and use medications exactly as directed. If you want to get more high-quality information, you can contact YaoDe. YaoDe will do its best to learn more about high-quality overseas drugs for you.