How much does a bottle of genuine Acemini cost in 2024?

Asciminib (Asciminib) is the first BCR::ABL1 inhibitor that specifically targets the myristoyl pocket (STAMP) of ABL. Based on the results of a pivotal Phase 3 study (ASCembl) and a Phase 1 dose-finding study (NCT 02081378), Asiminib was approved by the U.S. Food and Drug Administration (FDA) in 2021 for the treatment of adults with Philadelphia chromosome-positive CML-CP and BCR::ABL1 T315I mutation who had received ≥2 prior TKIs, and was subsequently approved in other countries.

The major molecular response (MMR) rate at week 96 (a key secondary endpoint) was 37.6% for asiminib and 15.8% for bosutinib; after adjusting for baseline MCyR, the difference in MMR rate between the two groups was 21.7% (95% CI, 10.53-32.95; two-sided p=0.001). Compared with bosutinib, aximinib had fewer grade ≥3 adverse events (AEs) (56.4% vs 68.4%) and AEs leading to treatment discontinuation (7.7% vs 26.3%). Compared with bosutinib, a higher proportion of patients treated with aximinib continued to benefit over time, supporting aximinib as a standard treatment option for CML-CP patients who have received ≥2 prior TKIs.

The original drug of Asiminib has not yet been launched in China, so it cannot be included in the medical insurance. The original drug of Asiminib sold overseas is very expensive. The price of 20mg*60 oral tablets is about more than 20,000 US dollars, which is about 150,000 yuan in RMB. There are also Assimini generic drugs produced and marketed overseas, and their drug ingredients are basically the same as those of the original drug. For example, the price of 40mg*60 tablets produced by a Laos pharmaceutical factory may be more than 4,000 yuan per box (the price may fluctuate due to exchange rates). The price is relatively cheap. For more information about overseas drugs and specific prices, please consult Yaode Medical Consultant.