How much does the 2024 Acemini replica cost?

Asciminib (Asciminib) The original drug has been launched in many countries. It is understood that there are also countries overseas that produce generic drugs of Asciminib. Its pharmaceutical ingredients are basically the same as those of the original drug, and it is suitable for treating previous Two types of tyrosine kinase inhibitors (TKIs) are used to treat patients with drug-resistant or intolerant chronic phase chronic myeloid leukemia (CML) and patients with T315I mutation. There may be slight differences in production specifications and prices. Common generic drug manufacturers include Laos Lucius Pharmaceuticals, etc.

The first allosteric myristoyl inhibitor aceminib, previously known as ABL001 in its development program, works by binding to the myristoyl pocket of the BCR::ABL1 protein. Aximinibinds independently of the ATP binding pocket (to which all other currently available TKIs bind), mimicking myristoyl pocket interactions and inhibiting BCR::ABL1 activity.结构分析表明药物与BCR::ABL1、ABL1和ABL2的结合相对特异，几乎没有脱靶结合。 Pharmacokinetic studies following a single 40 mg dose indicate that it is not significantly affected by renal or hepatic dysfunction, although further data and clinical experience at other dose levels are awaited.

The original drug of Asiminib has not yet been launched in China, so it cannot be included in the medical insurance. The original drug of Asiminib sold overseas is very expensive. The price of 20mg*60 oral tablets is about more than 20,000 US dollars, which is about 150,000 yuan in RMB. The generic drug of Asiminib produced by Laos Pharmaceutical Factory, with a specification of 40mg*60 tablets, may cost more than 4,000 yuan per box (the price may fluctuate due to the exchange rate). The price is relatively cheap. For more information about overseas drugs and specific prices, please consult Yaode Medical Consultant.