The main targets of capmatinib include

The main target of capmatinib is METkinase, also known as muscle fibroblast growth factor receptor (Mesenchymal Epithelial Transition Factor). METKinase is a receptor tyrosine kinase that belongs to the tyrosine kinase family. Its normal function involves regulating biological processes such as cell growth, migration, differentiation, and survival.

Under normal physiological conditions, METkinase activates downstream signaling pathways by binding to its ligand myofibroblast growth factor (Hepatocyte Growth Factor, HGF) and participates in regulating the normal physiological functions of cells. However, under certain pathological conditions, abnormal activation of MET kinase is closely related to the occurrence and development of various cancers, including non-small cell lung cancer (NSCLC).

Capmatinib is unique in that it specifically inhibitsMETkinase activity. By binding to METkinase, capmatinib blocks the conduction of the METkinase signaling pathway, interferes with the growth, differentiation and migration of tumor cells, thereby inhibiting the progression of cancer.

For NSCLC patients who carry METexon14 skipping mutations, this mutation will lead to abnormal activation of MET kinases and become a driving factor for lung cancer. Therefore, the targeting effect of capmatinib has significant efficacy in this specific patient group, providing them with an individualized and targeted treatment option.

Capmatinib is not currently available in China, so patients cannot purchase it domestically and need to purchase it through overseas channels. Currently, there are Hong Kong version of original drugs and foreign original drugs and generic drugs. The price of Hong Kong version of original drugs is about 35,000 yuan. The overseas original drugs are mainly European version of original drugs, and the price is more than 50,000 yuan, so original drugs are still relatively expensive. Generic drugs on the market abroad are much cheaper, mainly Laos generic drugs, the price is around 3,000 to 4,000 yuan, and the ingredients of original drugs and generic drugs are basically the same.