Is ixazomib a chemotherapy drug or a targeted drug?

Ixazomib is a targeted drug. Ixazomib belongs to the proteasome inhibitor class of drugs. Its working principle is to help kill cancer cells. Ixazomib is used in combination with lenalidomide (Revlimid) and dexamethasone to treat multiple myeloma (a cancer of the plasma cells of the bone marrow) that has gotten worse after treatment with other chemotherapy drugs.

In vitro studies have shown that ixazomib induces apoptosis in multiple myeloma cells that are sensitive or resistant to other conventional therapies, and in mouse xenograft models, ixazomib induces tumor growth inhibition. Ixazomib is a N-terminal dipeptidyl leucine boronic acid that reversibly inhibits the CT-L proteolytic (β5) site of the 20S proteasome. At higher concentrations, ixazomib also appears to inhibit the proteolytic β1 and β2 subunits and induce the accumulation of ubiquitinated proteins. After oral administration, the time to reach maximum concentration in plasma is 1 hour. The mean absolute oral bioavailability is 58%.

Citric acidThe molecular formula of ixazomib isC20H23 and its molecular weight is 517.12. Citrateixazomibhas a chiral center and is theR-stereoisomer. At 37°C, the solubility of ixazomib citrate in 0.1Nhydrochloric acid (pH 1.2) is 0.61 mg/mL (as ixazomib). Solubility increases with pH value. Ixazomiboral capsules contain 4, 3 or 2.3 mg of ixazomib, respectively, equivalent to span>5.7, 4.3 or 3.3mg citrateixazomib. Inactive ingredients include microcrystalline cellulose, magnesium stearate, and talc. The capsule shell contains gelatin and titanium dioxide. 4mg capsule shell contains red and yellow iron oxide, 3mg capsule shell contains black iron oxide, 2.3mg capsule shell contains red iron oxide. Printing ink contains shellac, propylene glycol, potassium hydroxide and iron oxide black. The retail price of Lucius Pharmaceuticals in Laos 4mg*3 tablets 900yuan. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.