Palbociclibis a kinase inhibitor used to treat hormone receptor(HR)positive, human epidermal growth factor receptor2 Adult patients with (HER2)negative advanced or metastatic breast cancer, in combination with an aromatase inhibitor as initial endocrine-based therapy or fulvestrant for the treatment of disease progression after endocrine therapy.
OralIBRANCEcapsules contain 125mg, 100mg or 75mg of the kinase inhibitor palbocillin. The molecular formula of palbocillin isC24H29N7O2. The molecular weight is 447.54Daltons. The chemical name is 6-acetyl-8-cyclopentyl-5-methyl Base-2-{[5-(piperazine-1-base)pyridinePyridine span>-2-yl]amino}pyrido[2, 3-d]pyrimidine-7(8H)-one. Palbocicillin is a yellow to orange powder with a pKa of 7.4 (secondary piperazine nitrogen) and 3.9 (pyridine nitrogen). Palbocicillin behaves as a highly soluble compound at pH values u200bu200bat or below 4. When pH is higher than 4, the solubility of the drug is significantly reduced. Inactive ingredients include microcrystalline cellulose, lactose monohydrate, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate, and hard gelatin capsule shell. Light orange, light orange/Caramel and caramel opaque capsule shells contain gelatin, red iron oxide, yellow iron oxide and titanium dioxide; printing ink contains shellac, titanium dioxide, ammonium hydroxide, propylene glycol and dimethicone. Palbociclib capsules are taken by mouth with an aromatase inhibitor or fulvestrant with food. The recommended starting dose is 125 mg once daily with food for 21 days and then off for 7 days. Based on individual safety and tolerability, dosing interruption and/or dose reduction are recommended. Original drugs in Hong Kong cost around 1 million, while generic drugs cost around 7more than 7more than 4 more than 1,000 per box. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.
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