View now: Latest prices and purchasing information for Seleniso in 2024

Selinexor is a nuclear protein transport inhibitor that is widely used to treat some blood system cancers such as multiple myeloma (MM). This drug has a unique mechanism of action. It interferes with the transport process of nuclear proteins in cells and affects the protein distribution in cells, thereby inhibiting the growth and proliferation of cancer cells.

Seleniso is already on the market in China and has been included in medical insurance, but its price is quite expensive, about 10,000 to 20,000 yuan, making patients bear higher treatment costs. It is recommended to consult the local hospital pharmacy for specific prices and medical insurance reimbursement status.

Different from the domestic market, there are two options for seliniso in the foreign market: original drugs and generic drugs. The original drug is the American version of the original drug. Because of its higher research and development costs, the price is even more expensive, even as high as hundreds of thousands of yuan. In comparison, generic drugs are more affordable. Lao generic drugs are one of the relatively low-priced generic drugs, with prices ranging from 2,000 yuan to 4,000 yuan. Compared with original drugs, they are more affordable. The ingredients of original drugs and generic drugs are basically the same.

The intracellular transport of nuclear proteins is critical to maintaining normal cell functions and regulating gene expression. Seleniso prevents the normal transport of specific proteins by inhibiting the activity of the nuclear protein transporter XPO1 (Exportin 1 ). This effect leads to the accumulation of some key proteins in the nucleus, affecting normal cell regulation, especially for cancer cells, preventing their abnormal proliferation.

In the treatment of multiple myeloma, selinesol is typically used in patients who have experienced an irreversible response to conventional treatments or have had disease relapse. By modulating the trafficking of nuclear proteins, selinexol is expected to prevent the overgrowth of malignant plasma cells, thereby slowing or halting tumor progression.