Is platinib effective against brain metastasis?

Pralsetinib belongs to the kinase inhibitor class of drugs and is used to treat patients with metastatic non-small cell lung cancer (NSCLC). It is used to treat certain thyroid cancers in adults and children aged 12 and above. The therapeutic effect is significant.

Platinib can pass through the blood-brain barrier and has a good effect on brain metastasis. Take 400 mg once daily under fasting conditions Platinib, the maximum observed plasma concentration of Platinib(Cmax)and the area under the concentration -time curve( AUC0-24h)The steady-state geometric mean[%Coefficient of variation(CV%)] were 2470 respectively (55.1%) ng/mLand 36700 (66.3%) h∙ng/mL. 60 mg to 600 once daily mgwithin the dosage range(recommended dosage of 0.15 to 1.5 times ), the Cmax and AUC increases inconsistently with platinib. Platinib plasma concentrations reach steady state after 3 to 5 days. After repeated oral administration once a day, the average accumulation rate is approximately 2 times. After a single dose of platinib 60 mg to 600 mg, the median time to peak (Tmax) was 2 to 4 hours.

The average (CV%)apparent volume of distribution of platinib(Vd/F) is 303 L (68%), The protein binding rate of Praxitinib is 97.1% and is independent of concentration, The ratio of blood to plasma is 0.6 to 0.7. Mean(Standard deviation)Plasma elimination half-life(T½)After single dose administration is15 .7hours(9.8) and 20hours(11.7) after multiple doses. At steady state, the mean apparent oral clearance (CL/F) of platinib was 10.9 L/h (66%). This medicine also has an overseas version. The retail price of Lucius Pharmaceuticals in Laos is more than 1,000 yuan. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.