Does Enasidenib work quickly?

Enasidenib (Enasidenib) is a drug that treats a specific type of leukemia (acute myeloid leukemia). The drug helps control the progression of the disease by suppressing the effects of certain genetic mutations. Regarding how quickly ensidipine takes effect, the specific effects will vary depending on individual circumstances. After starting the medication, it may take several months to see noticeable improvement. Therefore, the therapeutic effect of ensidipine is not immediately apparent and requires patience.

Ensidipine belongs to an emerging class of epigenetic drugs. These drugs correct the misdirection of gene activity due to the way DNA is packaged in cells, and it can take up to six months of treatment to see a response. In a study published in 2017, patients with acute myeloid leukemia had an overall response rate of 40%, a median overall survival of 9.3 months, and an estimated one-year survival rate of 39%. For the 34 people (19.3%) who achieved a complete response, the median survival was 19.7 months. The study did not directly compare ensidipine to standard-of-care chemotherapy, but historically the average survival time for patients with relapsed or refractory acute myeloid leukemia has been about three months. Therefore, the extension of survival time is significant.

Encidipine research medicine is not currently on the market in China, so it cannot be included in medical insurance. The price of ensidipine plain medicine when it is launched overseas is very high, and the price of each box may be around 30,000 yuan (the price may fluctuate due to the exchange rate). Currently, there are cheaper generic ensidipine drugs produced by other pharmaceutical companies overseas. For example, the price of Specification50mg*30 tablets produced by a Laos pharmaceutical factory may be more than 2,000 yuan per box (the price may fluctuate due to the exchange rate). Its pharmaceutical ingredients are basically the same as those of the original drugs sold abroad. For more information on overseas drug prices and specific information, please consult Yaode Medical Consultant.