What are the precautions for Seleniso?

Selinexor is an anti-tumor drug used to treat relapsed or refractory multiple myeloma(MM) and relapsed or refractory diffuse largeB cell lymphoma. What are the precautions for Seleniso?

Watch for thrombocytopenia. Commonly occurring during selinesol treatment, bleeding, including rare fatal bleeding, may occur.

Monitor platelet counts at baseline, during treatment, and as clinically indicated and more frequently during the first 3 months of treatment. Promptly evaluate any signs or symptoms of bleeding. Give platelet transfusions or other supportive treatments (such as thrombopoietin receptor agonists such as romiplostim and eltrombopag) as clinically indicated. It may be necessary to interrupt treatment, reduce dose, or stop treatment.

Neutropenia, including febrile neutropenia, may occur, which may increase the risk of infection. Median onset of action varies with dose and indication, range 23-32 days. MonitorANC at baseline, during selinesol treatment and as clinically indicated and more frequently during the first 3 months of treatment. Monitor patients for signs or symptoms of infection and conduct prompt evaluation. According to clinical indications, supportive treatment is given, including anti-infective drugs and growth factors such as granulocyte colony-stimulating factor (G-CSF). Treatment interruption, dose reduction, or permanent discontinuation may be necessary.

Gastrointestinal toxicity symptoms appear. Gastrointestinal toxicity is common and includes nausea, vomiting, diarrhea, or anorexia. The median time to the first episode of nausea or vomiting varied by dose and indication, ranging from 3 to 6 days and from 5 to 8 days, respectively. The median time to onset of anorexia was 8 days with the 80 mg dose and 35 days with the 100 mg once-weekly dose. The median time to onset of diarrhea is 12-50 days, and the median time to weight loss is 12-50 days.15 days in the 80 mg twice weekly dose group and 58 days in the 100 mg once weekly dose group.使用5-HT进行预防性止吐治疗3受体拮抗剂或其他止吐药。 Monitor weight, nutritional, and volume status at baseline, during treatment, and as clinically indicated.在治疗的前3个月，更频繁地监测体重。

Manage gastrointestinal toxicity as clinically indicated (e.g., antiemetics, antidiarrheals, appetite stimulants, nutritional support). Treatment interruption, dose reduction, or permanent discontinuation may be necessary.在整个治疗过程中，患者应保持足够的液体和热量摄入。根据临床指征提供营养支持、液体和电解质补充。

Hyponatremia occurs.塞利尼索治疗期间经常出现低钠血症。 The median time to first event was 80 mgtwice weekly8 days and 100 mgonce weekly 21 days. Monitor serum sodium concentration (corrected for concurrent hyperglycemia and high serum paraprotein concentration) at baseline, during treatment with selinesol and as clinically indicated.在治疗的前两个月，更频繁地进行监测。 Sodium concentration corrected for concurrent hyperglycemia(serum glucose concentration> 150 mg/dL)and high serum paraprotein concentration. Treat hyponatremia as clinically appropriate(eg, intravenous saline or oral sodium supplementation) including dietary review. Treatment interruption, dose reduction, or permanent discontinuation may be necessary.

A serious infection occurs. Infection, sometimes fatal. The most commonly reported infections include upper respiratory tract infections, pneumonia, and sepsis.大多数感染与中性粒细胞减少症无关，是由非机会性微生物引起的。 The median onset of grade 3 or higher infection, pneumonia, or sepsis was 42, 54, or 42 days, respectively.监测感染的迹象和症状，并及时治疗任何感染。

Neurotoxicity symptoms appear. Adverse neurological effects may occur, including dizziness, syncope, decreased level of consciousness, vertigo, amnesia, drowsiness, hallucinations, and mental status changes (including delirium and confusional states). The median time to first neurological adverse reactions in clinical trials was15to29 days. Optimize hydration status, hemoglobin concentration, and concomitant medications to avoid potential worsening of dizziness or mental status changes. Avoid feeling dizzy or confused. Implement fall prevention measures if directed.

Embryotoxicity occurs. Based on its mechanism of action and animal experiment results, it may cause harm to the fetus, Confirmed teratogenicity and growth changes in animals. Assess pregnancy status before initiating treatment with selinesol. Advise women of childbearing potential and their partners to use effective contraception during treatment and for 1 week after the last dose. Inform patients of potential fetal risks.

Cataract appears. New onset or worsening of cataracts may occur. Among patients who developed cataracts when initiating treatment with selinesol, the median time to new cataract development was 228 days and the median time to cataract progression was 237 days. May cause new or worsening cataracts, monitor for changes in vision. The cost of each box of generic drugs is about three to four thousand yuan. For details, please consult overseas pharmaceutical institutions. If you want to get more high-quality information, you can contact YaoDe. YaoDe will do its best to learn more about high-quality overseas drugs for you.