How much does Ensidipine cost in India?

Enasidenib (Enasidenib) currently does not have an Indian version of the original drug or generic version. Encidipine generic drug has been marketed in many countries, such as the United States. It is understood that there are also countries overseas producing generic drugs of encidipine. Its pharmaceutical ingredients are basically the same as those of the original drug. It is an oral selective small molecule drug that can inhibit the production of 2-HG catalyzed by the mutant IDH2 enzyme and promote the differentiation of leukemic myeloblastic cells.

In August 2017, ensidipine was approved in the United States for the treatment of adult patients with mutant IDH2 R/R acute myeloid leukemia (AML). 13 This approval was based on the results of a pivotal single-arm Phase 1/2 study in patients aged ≥18 years with IDH2 gene-mutated hematological malignancies. In this trial, among 214 patients with mutant IDH2 AML who had previously received AML treatment, the overall response rate (ORR) was 38.8%, the complete response (CR) rate was 19.6%, and the median OS was 8.8 months. Among 157 patients who were red blood cell (RBC) and/or platelet transfusion dependent at baseline, 53 (34%) patients were no longer dependent on RBC and platelet transfusions.

Encidipine research medicine is not currently on the market in China, so it cannot be included in medical insurance. The price of ensidipine plain medicine when it is launched overseas is very high, and the price of each box may be around 30,000 yuan (the price may fluctuate due to the exchange rate). Currently, there are cheaper generic ensidipine drugs produced by other pharmaceutical companies overseas. For example, the price of Specification50mg*30 tablets produced by a Laos pharmaceutical factory may be more than 2,000 yuan per box (the price may fluctuate due to the exchange rate). Its pharmaceutical ingredients are basically the same as those of the original drugs sold abroad. For more information on overseas drug prices and specific information, please consult Yaode Medical Consultant.