How much does a box of bosutinib cost in 2024?

Bosutinib (Bosutinib) is a selective Src/c-Abl tyrosine kinase inhibitor approved for the treatment of chronic myelogenous leukemia (CML), especially suitable for newly diagnosed patients Discontinued chronic phase (CP) Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+CML); and patients 1 year and older with chronic phase, accelerated phase (AP), or blast phase (BP) Ph+CML, or who are resistant or intolerant to previous therapy.

The Bcr-Abl fusion gene expressed in CML is involved in leukemia cell proliferation through its sustained activation, and bosutinib inhibits this process. It was observed in clinical studies that higher bosutinib exposure was associated with a greater likelihood of response and a greater likelihood of safety events. The time course of the pharmacodynamic response to bosutinib has not been fully determined. Following a single oral dose of 500 mg bosutinib and ketoconazole, a strong CYP3A inhibitor, bosutinib does not prolong the QT interval to any clinically relevant extent. There are two known absolute contraindications to bosutinib, namely known hypersensitivity to bosutinib and hepatic impairment.

The originator drug of bosutinib is not marketed in the country, so it cannot be included in medical insurance. Currently, the original drugs sold overseas include Turkish version and European version. The price of the Turkish version may be more than RMB 2,000 per box of 500mg*28, and the price of the European version may be more than RMB 30,000 (the price may fluctuate due to the exchange rate). There are also bosutinib generic drugs produced overseas in other countries. Their pharmaceutical ingredients are basically the same as those of the original drug. The price of 500mg*30 per box may be more than 2,000 yuan (the price may fluctuate due to the exchange rate), and the price is relatively cheap.