What are the side effects of teriflunomide?

Teriflunomide is a pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties, used to treat patients with relapsing-remitting multiple sclerosis (ms). Teriflunomide is the active metabolite of leflunomide and acts as an immunomodulator by inhibiting pyrimidine synthesis.

Common side effects of teriflunomide include headache (19-22%), diarrhea (15-18%), increased alanine aminotransferase (12-14%), hair loss (10-13%), Influenza (9-12%), Nausea (9-14%), Paresthesia (9-10%), Phosphateemia (5-18%), URTI (9%), Bronchitis (5-8%), Upper abdominal pain (5-6% ), Sinusitis (4-6%), Musculoskeletal pain (4-5%), Hypertension (4%), Toothache (4%), GGTIncrease (3-5%), Anxiety (3-4%), Myalgia (3-4%), Pruritus (3-4%), Blurred vision (3%), Cystitis (2-4%), Viral gastroenteritis (2-4%< span>), Oral herpes (2-4%), Neutropenia (2-4%) , Elevated aminotransferases (2-3%), Seasonal allergies (2-3%), Burning sensation (2-3%), Heart palpitations (2-3%), Weight loss (2-3%), Decreased neutrophil count (2-3%), Sciatica (1-3%), Conjunctivitis (1-3%), Increased white blood cells (1-3%) , Acne (1-3%), Carpal tunnel syndrome (1-3%), Leukopenia (1-2%), Abdominal distension (1-2%)

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