Medication Guide: How many boxes of adagrasib should be taken a month?

Adagrasib is indicated for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC) who have received at least one prior systemic therapy. Before treatment, doctors will select patients with locally advanced or metastatic non-small cell lung cancer to use adagrasib based on the presence of KRAS G12C mutations in plasma or tumor specimens. If no mutations are detected in the plasma specimen, tumor tissue is tested.

The recommended dose of adagrasiib is 600 mg orally twice daily until disease progression or unacceptable toxicity. Take it at the same time every day, with or without food. Adverse events may occur during the patient's treatment with adagrasiib. The doctor will adjust the drug dose according to the severity of the condition. The first dose will be reduced to 400 mg orally twice a day, and the second dose will be reduced to 600 mg orally once a day. A maximum of two dose reductions are allowed. Patients who cannot tolerate 600 mg once daily should permanently discontinue adagrasiib.

Sinceadagrasibthe original drug has not yet been launched in China, patients can only purchase adagrasib through overseas channels. The specifications of the original American version200mg*180 tablets per box are more than 100,000 yuan (the price may fluctuate due to the exchange rate), which is very expensive. It is roughly estimated that patients need about one box a month, provided that the patient does not adjust the drug dosage. Currently, there are no generic drugs of adagrasib produced overseas. For more drug information and specific prices, please consult Yaode’s medical consultant.