Are the side effects of adagrasib serious?

In clinical studies,Adverse reactions (side effectsAE) associated with Adagrasib (Adagrasib)Usually mild to moderate severity, manageable with concomitant medication and dose adjustment;87% of patients were treated with antiemetics and 48% with antidiarrheals, but the discontinuation rate of adagrasiib due to TRAEs was low (7%). The most common adverse reactions are related to the gastrointestinal tract and should be managed with supportive care, antidiarrhea, and antiemesis. Taking adagrasiib as a tablet with food may help manage gastrointestinal-related adverse events.

The most common adverse reactions are nausea, diarrhea, vomiting, fatigue, musculoskeletal pain, liver toxicity, renal impairment, edema, and dyspnea. Adagreb-related TRAEs are generally mild and manageable with dose adjustment (interruption and/or reduction), concomitant medication (e.g., antidiarrheal agents and antiemetics), lifestyle changes, and individualized patient counseling. For exampleManagement strategies to reduce diarrhea include dietary modifications such as eating small, frequent meals and avoiding greasy or spicy foods, milk, caffeine, and alcohol. If diarrhea occurs, patients may benefit from a B-R-A-T diet (bananas, rice, applesauce, toast/decaffeinated tea) and staying fluid (6-8 large glasses of water, clear liquids, or soups per day).

Since the original drug of adagrasib has not yet been launched in China, patients can only purchase adagrasib through overseas channels. The specifications of the original version of adagrasib in the United States The price of each box of 200mg*180 tablets is more than 100,000 yuan (the price may fluctuate due to the exchange rate), which is very expensive. Currently, there are no generic adagrasibu produced in other countries overseas. For more drug information and specific prices, please consult Yaode Medical Consultant.