How long does it take for resistance to seputinib/serpatinib to develop?

Selpercatinib has durable efficacy, including intracranial activity. Seputinib is a targeted therapy drug that targets specific genetic mutations and is used to treat certain thyroid and lung cancers. Drug resistance means that tumor cells develop resistance to drugs, resulting in treatment failure. However, tumor cells may evade the inhibitory effects of drugs through genetic mutations or other mechanisms, leading to the development of drug resistance.

Currently, there are insufficient long-term data on resistance to seputinib. Since each patient's situation is different, the time to resistance will also vary. Some studies suggest that resistance may develop in some patients treated with seputinib; while other patients may continue to benefit from the drug for a longer period of time. To maximize the duration of effective treatment with Seputinib, it is recommended to follow your doctor's recommendations and treat at the prescribed dose and duration. In the meantime, get regular checkups to detect drug resistance early and discuss possible treatment options with your doctor.

Up to now, the original research drug is sold in China under the name of Seputinib, but it is not included in medical insurance. The price of each box of 80mg*56 tablets may be more than 10,000 yuan. There are European and American versions of the original drugs sold overseas, with the price of each box ranging from 20,000 to more than 100,000 yuan (prices may fluctuate due to exchange rates). Generic drugs of Seputinib have also been put on the market for sale overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 40mg*120 capsules produced by a Laos pharmaceutical factory is more than RMB 4,000 per box (the price may fluctuate due to exchange rates).