What is the name of the domestic version of Trametinib?

There are currently four MEK1/2 inhibitors approved for marketing globally. Among them, only trametinib was approved for marketing in China in December 2019. Therefore, the name of the original drug of trametinib marketed in China is trametinib.

Trametinib (Trametinib) is a reversible inhibitor of the kinase activity of mitogen-activated extracellular signal-regulated kinase1 (MEK1) and MEK2 kinase. It is primarily used to treat unresectable or metastatic melanoma associated with BRAF (murine sarcoma oncogenic homolog B1) V600E or V600K mutations.

Trametinib can inhibit the growth of BRAF V600 mutation-positive cancer cells by inhibiting MEK. The feature of the drug is that trametinib and dabrafenib are the first drugs approved for combined treatment of melanoma. Trametinib combination therapy is approved for advanced melanoma when the melanoma cannot be removed by surgery or the cancer cells have spread.

It has many adverse reactions, and common or serious adverse reactions include skin and subcutaneous tissue diseases, gastrointestinal disorders, neurological diseases, respiratory diseases, musculoskeletal diseases, metabolic and nutritional disorders, insomnia, etc. In addition, the drug may also cause serious adverse reactions such as primary malignant tumors, bleeding, venous thromboembolism, cardiomyopathy, interstitial lung disease, severe skin toxicity, severe febrile reactions, and hyperglycemia.

It should be noted that trametinib is a prescription drug and must be used under the guidance of a doctor. Before using trametinib, please consult your doctor to learn about the usage, precautions and possible adverse reactions of the drug.

Trametinib has been launched in the domestic market and has been included in medical insurance. Patients can purchase it domestically at an approximate price of more than 10,000 yuan. The price is relatively high, but you need to consult the local hospital pharmacy for specific costs. In foreign countries, the price of trametinib is relatively low, mainly because there are many generic drugs to choose from, especially the generic drugs produced in Laos, which cost about one to two thousand yuan, which is much cheaper than in China. It should be noted that the ingredients of foreign generic drugs and domestic original drugs are basically the same.