Which is better, the generic drug or the original drug of pemetinib/pemetinib?

Pemigatinib/Pemigatinib is a drug used to treat cholangiocarcinoma. When choosing to use pemigatinib, you usually pay attention to its efficacy, safety and quality.

The generic drug of pemetinib is similar to the original drug in terms of drug ingredients. Pemetinib is a kinase inhibitor indicated for the treatment of previously treated unresectable locally advanced or metastatic cholangiocarcinoma with fibroblast growth factor receptor 2 (FGFR 2) fusion or other rearrangement detected by a U.S. Food and Drug Administration (FDA)-approved test. In the FIGHT 202 trial, potentially targeted oncogenic driver alterations were detected in 44.5% of enrolled patients. Four of 20 patients without fused/rearranged FGFR2 carried the p.C382R mutation. Among the 10 cases, 3 patients also developed BAP1 variants and responded to treatment. The three patients' best overall responses were stable disease with tumor shrinkage of 26% and 30.6%, with reported progression-free survival (PFS) of 6.9, 4.0, and 9.0 months.

The original drug of pemetinib was first developed by a pharmaceutical company and approved for marketing. It has sufficient clinical trial data to support its efficacy and safety. A lot of resources and time have been invested in the research and development process of original drugs, so the price is relatively high. The price of original drugs sold in China may be RMB 30,000 to RMB 50,000. The price sold overseas may be around RMB 70,000 (the price may fluctuate due to exchange rates). Generic drugs are drugs that other pharmaceutical companies can copy and produce according to the production process and quality standards of the original drug after the patent of the original drug expires. Generic drugs are relatively more affordable, and the price produced by a Lao pharmaceutical factory may be more than 1,000 yuan (the price may fluctuate due to the exchange rate).