What is the price of pemetinib/pemetinib targeted drug in 2024?

The FGFR tyrosine kinase inhibitor (TKI) pemigatinib has been introduced into the treatment of advanced cholangiocarcinoma for relapsed or refractory myeloid/lymphoid tumors with FGFR2 and FGFR1 rearrangements, respectively. Several clinical trials are currently investigating possible combinations of pemetinib and immunotherapy. Pemetinib is a targeted therapy drug that targets specific gene fusions and is mainly used to treat malignant tumors such as cholangiocarcinoma. Its price will fluctuate in different regions, different manufacturers and different points in time.

For originator drugs, which are drugs developed and marketed for the first time, prices are usually higher. This is mainly because a large amount of manpower, material and financial resources are invested in the research and development process of original drugs, including costs in clinical trials, production process development and optimization, quality control and other aspects. In addition, the original drug enjoys exclusive sales rights during the patent protection period, which will also lead to a relatively high price. The original drug Pemetinib sold in China is not yet eligible for medical insurance. It is available in two specifications: 4.5 mg*14 tablets and 9mg*14 tablets. The price of each box may be RMB 30,000 or RMB 50,000. The original drug Pemetinib sold overseas, with a specification of 13.5mg*14 tablets, may cost around RMB 70,000 per box (the price may fluctuate due to exchange rates).

Generic drugs are drugs produced by other pharmaceutical companies according to the standards and specifications of the original drug after the patent of the original drug expires. Since generic drugs do not need to bear the high costs of research and development of original drugs, their prices are usually lower. For example, the price of a box of 4.5mg*14 tablets produced by a Lao pharmaceutical factory may be more than 1,000 yuan (the price may fluctuate due to the exchange rate). Its drug ingredients are basically the same as those of original drugs sold domestically and abroad.