Is Eltrombopag/Eltrombopag available in Bangladesh?

Eltrombopag/Eltrombopag is a thrombopoietin receptor agonist with excellent therapeutic effect on immune thrombocytopenia (ITP). The original drug of eltrombopag is currently marketed and sold in many overseas countries. It is understood that the Bangladeshi version of the generic version of Eltrombopag is currently produced and sold. Its pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. There may be slight differences in production specifications and prices. Common manufacturers include Bangladesh Yaopin International, Everest Pharmaceuticals, Beacon Pharmaceuticals, etc.

Eltrombopag is a low molecular weight synthetic non-peptideTPO-R agonist. It has excellent oral bioavailability, reaching peak concentration in 2-6 hours after oral administration and having a half-life of 21-32 hours. It is highly bound to human plasma proteins. Unlike native thrombopoietin, which binds to the extracellular domain of the thrombopoietin receptor, eltrombopag selectively binds to the transmembrane domain of the receptor. It stimulates megakaryopoiesis through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway. Eltrombopag did not affect agonist-induced platelet aggregation or activation in in vitro and ex vivo studies using platelet samples from healthy volunteers and patients with chronic ITP.

Eltrombopag is available in tablet form, each film-coated tablet containing 25 or 50 mgEltrombopag (Eltrombopag) Currently, the price of the original drug of Eltrombopag on the market at home and abroad is several thousand yuan, while the price of each box of the generic drug of eltrombopag sold overseas may be several hundred yuan (the price may fluctuate due to the exchange rate), which is cheaper than the original drug, giving patients more choices.