Sotoracib (AMG510) Chinese detailed instructions

1. Drug name

Common name: Sotolaxib (AMG510)

Product name:Sotorasib

2. Ingredients

Main ingredients: sotolaxib (AMG510)

3. Indications

Sotoracib (AMG510) is suitable for KRAS G12C mutated advanced or metastatic tumors, including but not limited to non-small cell lung cancer, colorectal cancer, etc.

4. Pharmacological effects

Sotoracib (AMG510) is a new type of anti-cancer drug that is a targeted therapy for KRAS G12C mutations. KRASgene mutations are common in many cancer types, and KRAS G12Cmutation is the most common one.

The drug binds to the specific site ofRAS protein and inhibits its activity, thereby blocking the abnormal activation of cancer cell signaling pathways. This mechanism is expected to inhibit the growth, proliferation and spread of tumor cells, thereby achieving the effect of treating tumors.

5. Drug specifications

Dosage form: tablet

Specifications: Each tablet contains a specified dose of sotorasiib (AMG510)

6. Usage and Dosage

Usage: Oral

Dosage: Under normal circumstances, adjust the dosage according to the doctor's prescription and specific condition. It is generally recommended to take it once a day, each time960mg, and each dosage should be based on the doctor’s advice.

7. Adverse reactions

Sotoracib (AMG510) may cause some adverse reactions, including but not limited to:

1.Nausea and vomiting

2.Diarrhea

3.Fatigue

4.Skin reaction

5.Abnormal liver function

6.Hematological abnormalities (such as anemia, leukopenia)

7.Pulmonary inflammation

8.High blood sugar

9.Skeletal muscle diseases, etc.

If serious adverse reactions occur during use, you should seek medical treatment in time.

8. Taboo

Contraindicated for those who are allergic to drug ingredients. Use with caution by pregnant and lactating women.

9. Things to note

1.Before using sotoracib (AMG510), you should inform your doctor of your allergies, medical history, and other drugs you are taking, especially other anti-cancer drugs.

2.During the period of medication, liver function, hematological indicators, etc. should be monitored regularly, and physical conditions should be paid close attention to. If there is any abnormality, seek medical treatment in time.

3.During the medication period, you should avoid drinking alcohol and avoid using other drugs that affect liver function at the same time.

4.Pregnant women, lactating women and those planning pregnancy should consult a doctor before use.

5.Avoid simultaneous use with other drugs, especially drugs that affect blood coagulation function.

10. Storage method

1.Store in a cool, dry place, away from direct sunlight.

2.Keep out of reach of children.

11. Manufacturer

1.Manufacturer:AmgenCompany

2.Address: Thousand Oaks, California, USA

12. Validity period

Please refer to the date marked on the packaging.

13.Price and purchase

Currently, since Sosotoracib is not yet available in China, domestic patients cannot purchase it directly. Toracib is currently not on the market in the country, and domestic patients cannot purchase it directly. But they can choose to obtain the drug overseas. The overseas market for sotoraxib includes both original drugs and generic drugs. In the overseas market, sotorasibu exists in two forms: original drug and generic drug. Original drugs, especially the European version and Hong Kong version, are quite expensive, often reaching tens of thousands. However, in comparison, the prices of generic drugs in foreign markets appear to be more affordable.

Take generic drugs in Laos as an example. Recently, the prices of Lucius and Daxiong brands have been significantly reduced, and now only cost more than 1,000 to 2,000 yuan. This undoubtedly brings substantial economic relief to patients who need this drug. It is worth mentioning that the ingredients of these generic drugs are basically the same as those of the original drugs.

The above is the detailed Chinese instructions for Sotorasib (AMG510, Sotorasib). For specific information, please follow your doctor's advice and read the official instructions.