How much does a box of Sothoracib (AMG510) Laos Lucius cost?

Among the generic drugs currently on the market, there is the Lao Lucius version of sotorasibu (AMG510). The ingredients of the generic drugs produced by this pharmaceutical factory are basically the same as those of the original drug, but there may be differences in price, specifications, etc. It is currently known that the price of each box of 120mg*56 tablets is more than 1,000 yuan (the price may fluctuate due to the exchange rate), and the price is much cheaper than the original drug.

Sotoraxib is an oral, small molecule inhibitor of the KRAS gene product, a mutated oncogene commonly found in several forms of cancer, most commonly in non-small cell lung cancer (NSCLC). The KRAS (Christian murine sarcoma viral oncogene homolog) G12C mutation produces a protein that is continuously produced and stimulates excessive cell growth. Sotoraxib binds to and inhibits the abnormal KRAS gene product and is an inhibitor of KRAS. A potent inhibitor of cell growth and proliferation in G12C-mutated tumor cell lines and experimental tumor models, it is the first inhibitor of this oncogene protein and was found to induce objective responses in 36% of patients with refractory non-small cell lung cancer harboring the KRAS G12C mutation in a large open-label trial.

The recommended dose of sotoraxib is960 mg orally administered once daily until disease progression or unacceptable toxicity. Side effects of sotoraxib are common, occurring in nearly all patients treated with sotoraxib, and leading to dose modification or discontinuation in approximately one-third of treated patients. Common side effects include diarrhea, nausea and vomiting, abdominal pain, fatigue, myalgia, arthralgia, cough, dyspnea, lymphopenia, anemia, and elevated transaminases.