Comparison of domestic and foreign market pricing of Seleniso drugs

Selinexor (Selinexor), as a highly effective and selective oral nuclear transport inhibitor, has been certified by the U.S. Food and Drug Administration (FDA). The drug, often used in combination with low-dose dexamethasone, offers a new treatment option for adults with multiple myeloma (RRMM) whose disease has become resistant to multiple therapies after at least four prior lines of therapy.

In the clinical trial namedSTORM, selinesol showed significant effects and good tolerability in the treatment of RRMM. Trial data showed that 26% of patients achieved partial response or better, and the median duration of response was 4.4 months. In addition, in the modified intention-to-treat (mITT) patient population, median overall survival was extended to 8.6 months. Although the drug is effective, patients still need to pay attention to the possible side effects of the drug, such as thrombocytopenia, nausea, fatigue, anemia, loss of appetite, and weight loss. Fortunately, these adverse events can usually be effectively controlled with prompt medical care and medication dosage adjustments.

For domestic patients, the original drug Seleniso has been launched in the domestic market and has been included in the national medical insurance directory. This means that eligible patients can enjoy medical insurance reimbursement when purchasing this drug. It is understood that the domestic price of each box of Seleniso is about more than 20,000 yuan. However, for patients who need to import the U.S. version of selinesol, the cost of the drug is much higher. In overseas markets, the price of the American version of Seleniso with a specification of 20mg*8 tablets per box may be as high as more than 100,000 yuan, and the price may also change due to exchange rate fluctuations.

Generic versions of selinexol have also appeared in overseas markets. These generic drugs are basically the same as the original drugs in terms of drug ingredients, but the prices are relatively affordable. For example, a generic drug of selinesol produced by a Lao pharmaceutical factory with a specification of 20mg*32 tablets may be sold for only more than 2,000 yuan. Of course, when patients choose to purchase generic drugs, they also need to pay attention to possible price changes caused by exchange rate fluctuations.