Are there any in Paraguay in Seliniso? Can I buy it?

Currently, there are no original or generic drugs of Selinexor produced in Paraguay. There may be original drugs of Selinexor sold in Paraguay and other regions. It is understood that the manufacturer of Selinisoloriginal drug isKaryopharm Therapeutics Inc. It is already on the market for sale in the United States, China, the European Union, Canada and other regions, and there are also generic Selinisol drugs on the market. Its pharmaceutical ingredients are similar to the original drug.

Selinesol is the first selective inhibitor of nuclear export (SINE) XPO1 antagonist for the treatment of adult patients with relapsed or refractory multiple myeloma (RRMM) and diffuse large B-cell lymphoma (DLBCL). Like other selective inhibitors of nuclear export (SINEs), selinesol works by binding to exportin 1 (also known as XPO1 or CRM1). XPO1 is a nuclear protein that transports several proteins, including tumor suppressors, oncogenes, and proteins that control cell growth, from the nucleus to the cytoplasm; it is frequently overexpressed and dysfunctional in several types of cancer. By inhibiting the XPO1 protein, SINEs lead to the accumulation of tumor suppressors in the nuclei of malignant cells and reduce the levels of oncogene products that drive cell proliferation. This ultimately leads to cell cycle arrest and cancer cell death through apoptosis.

The original Seleniso drug currently on the domestic market and covered by medical insurance may cost more than RMB 20,000 per box. The US version of the original Seleniso drug, 20mg*8 tablets per box, is sold overseas, and the price may be more than 100,000 RMB (the price may fluctuate due to the exchange rate). The price is very expensive; the generic version of Seleniso produced by Laos Pharmaceutical Factory, the price of 20mg*32 tablets per box may be more than 2,000 RMB (the price may fluctuate due to the exchange rate).