How many boxes of Adagrasib can be consumed in a month and how much does it cost per month?

Adagrasib (Adagrasib) is an oral small molecule inhibitor of the KRAS gene product. It targets mutated oncogenes that are common in various forms of cancer, especially in non-small cell lung cancer (NSCLC). The KRAS (Kristen rat sarcoma viral oncogene homolog) G12C mutation results in the production of a constitutively active protein receptor belonging to the RAS GTPase family that stimulates excessive cell growth. Adagarasib effectively inhibits cell growth and proliferation in tumor cell lines and experimental tumor models with KRAS G12C mutations by binding to the abnormal receptor and locking it into an inactive conformation.

According to the clinical prescribing guidelines for adagrasiib, the recommended dose is 600 mg orally twice daily until disease progression or intolerable toxicity occurs. The current specification of the US version of the original drug is 200mg*180 tablets per box. It is roughly calculated that patients will need about 1 box for one month's use. The price of original drugs sold overseas may be 180,000 yuan (the price may fluctuate due to exchange rate effects), which is very expensive.

The latest news reports that the first overseas generic drug of adagrasibu has been developed and sold by Lucius Pharmaceutical Factory in Laos. The specification is 200mg*90 tablets per box. The price may be more than 4,000 yuan (the price may fluctuate due to the exchange rate). It is roughly calculated that a patient will need about 2 boxes for a month, and the cost for a patient to use it for a month may be less than 10,000 yuan.

Therefore, the dosage and cost of adagrasib will vary depending on the patient's specific situation and the source of the drug. When using adagrasib, patients should follow their doctor's recommendations to ensure the accuracy and safety of the medication.