Detailed Chinese instructions for Adagrasib

Drug name: Adagrasib

Drug ingredients: Adagrasib is aKRAS G12C inhibitor, the chemical name is (S)-1-(1-Aminocyclohexyl)-3-[3-(2- (6-Methoxy-8-(2-Methylpropoxy)-7-(3-(Trifluoromethyl)-5-Fluorophenyl)-7H-Pyrano[2, 3-c]Quinazole-4-ethyl]benzoic acid, its molecular formula isC₃₁H₃₆F₃N₃O₅, the molecular weight is 565.6g/mol .

Indications: Adagrasib is indicated for the treatment of patients with advanced or metastatic non-small cell lung cancer (NSCLC) harboring the KRAS G12C mutation, as well as other solid tumors with the same mutation.

Pharmacological effects: Adagorasib works by inhibiting the activity ofKRAS G12Cmutant. KRAS G12CThe KRAS G12C mutation is a mutation associated with a variety of cancers that causes excessive proliferation, growth, and spread of tumor cells. By blocking the activity of the KRAS G12C mutant, adagrasib interferes with the growth signaling of cancer cells, thereby inhibiting the growth and spread of tumors.

Usage and dosage:

1.Adults: The recommended dose is oral administration twice daily. Each dose was 600mg until efficacy no longer continued or unacceptable toxicity occurred.

2.Patients with hepatic impairment: Dosage adjustment may be required. In this case, please consult your doctor.

Adverse reactions:

1.The most common adverse reactions include: fatigue, nausea, vomiting, diarrhea, loss of appetite, rash, muscle spasm, high blood pressure, headache, etc.

2.Severe adverse reactions may include: liver function damage, interstitial lung disease, arrhythmia, eye inflammation, etc. If these symptoms occur, stop taking the medicine and seek medical advice immediately.

Contraindications:

1.Contraindicated in patients who are allergic to adagrasib or any ingredient in the drug.

2.Contraindicated for pregnant and lactating women.

3.With certain drugs (such as strongCYP3A4inhibitors and drugs such as Gleevec (glecaprevir) Direct antiviral drugs such as pan>/pibrentasvir (pibrentasvir) may cause serious adverse reactions when used simultaneously and should be avoided.

Notes:

1.While taking adagrasib, patients should be closely monitored for possible adverse reactions and undergo regular tumor evaluation.

2.Adherent caution is required when using adagrasiib in patients with cardiovascular disease or hepatic impairment, and dose adjustments may be required.

3.If the patient experiences serious adverse reactions or allergic reactions, he should stop taking the medicine immediately and seek medical advice.

4.Adagrasiib may interact with other drugs. Please inform your doctor of all medications you are taking, including prescription drugs, over-the-counter drugs, and supplements, before use.

Storage conditions:

1.Adagrasib should be stored in a cool, dry place away from direct sunlight.

2.Please keep medicines out of the reach of children to prevent children from accidentally eating them.

Availability and Pricing:

Since adagrasib is not yet available in the country, patients are currently unable to purchase it directly domestically and must resort to overseas channels. However, the original drug of adagrasib abroad, mainly from the United States, is extremely expensive, reaching more than 180,000 yuan, which is undoubtedly a heavy burden for ordinary families. But what is gratifying is that foreign generic drugs have recently come out. Among them, the generic drug of adagrasibu produced by Lucius in Laos has attracted much attention. Its price is relatively affordable, only about four to five thousand yuan per box. More importantly, after comparison, it was found that the ingredients of this generic drug are basically the same as the original drug, providing patients with a more economical and affordable choice.