How much does a box of genuine Enxidipine cost?

Enasidenib is an oral targeted drug used to treat a specific type of leukemia, namely refractory or relapsed acute myeloid leukemia (AML). It is an odor acid dehydrogenase 2 (IDH2) inhibitor that specifically inhibits the activity of the mutant IDH2 enzyme.

Ensidipine has not yet obtained marketing approval in China, which means that domestic patients cannot purchase the drug directly and must seek overseas purchase channels. In foreign countries, relatively affordable drugs are generic drugs, especially those produced in Laos and Bangladesh, which sell for between 2,000 and 4,000 yuan. It is worth mentioning that there is almost no difference in the pharmaceutical ingredients between these generic drugs and the original drugs.

Among AML patients, about 10% to 15% carry IDH2 gene mutations. This mutation prevents cells from normal differentiation, leading to the occurrence and progression of AML. The mechanism of action of ensidipine is by inhibiting the activity of mutant IDH2 enzyme, blocking abnormal metabolic pathways and restoring the normal differentiation function of cells.

Clinical trials have shown that ensidipine has shown significant efficacy in the treatment of IDH2mutated refractory or relapsed AML patients. It can reduce the number of leukemia cells, prolong patient survival, and achieve clinical responses of complete or partial remission in some patients.

Ensidipine is usually taken as an oral medication once daily. Before starting treatment, doctors usually test patients for genetic mutations to determine whether they carry the IDH2 mutation and evaluate the patient's general health and suitability for treatment.