How much does generic ensidipine Bangladeshi Ziska cost?

Enasidenib is an oral targeted inhibitor mainly used to treat specific types of acute myeloid leukemia (AML). AML is a type of leukemia caused by the proliferation of abnormal white blood cells in the bone marrow. Ensidipine is primarily used to treat patients with newly diagnosed, refractory or relapsed AML who have IDH2 (isocitrate dehydrogenase 2) mutations.

Encidipine is not yet available in the country, so patients cannot purchase it domestically and need to purchase it through overseas channels. The cheaper ones abroad are generic drugs, especially the Lao version of Lucius generic drugs and the Bangladeshi version of Ziska generic drugs. The prices range from more than 2,000 yuan to more than 4,000 yuan, and the ingredients of the original drugs and generic drugs are basically the same.

The mechanism of action of ensidipine is to treatAML by inhibiting the activity ofIDH2 mutant enzyme. In AML patients, IDH2 gene mutations cause the abnormally active IDH2 enzyme to produce large amounts of 2-hydroxyvaleric acid (2-HG) metabolite. This abnormal metabolite can interfere with the normal differentiation and proliferation of cells and promote the development of AML. The function of ensidipine is to inhibit the activity of IDH2 mutant enzyme, reduce the level of 2-HG and restore normal cell functions, thereby helping to control the development of AML.

Ensidipine is usually recommended to be taken orally daily at a dose of100mg. Prior to treatment, doctors typically conduct a detailed clinical evaluation to determine whether the patient is suitable for treatment with ensidipine. During the treatment process, the doctor may adjust the dosage according to the patient's specific condition and severity of the disease, and conduct regular monitoring to evaluate the efficacy of the treatment and the patient's safety.

Overall, ensidipine, as a targeted inhibitor, provides a new treatment option for patients with specific types ofAML. It helps control the development of AML by inhibiting the activity of IDH2 mutant enzyme and restoring normal cell functions. However, patients should receive a detailed evaluation from their physician before using ensidipine and follow their physician's recommendations to ensure optimal treatment.