What is the latest price of trifluridine and tipiracil (Longsiphor) in 2024?

Trifluridine (Lonsurf) contains two ingredients, trifluridine and tipiracil, and is indicated for the treatment of adult patients with metastatic colorectal cancer who have previously received chemotherapy based on fluoropyrimidine, oxaliplatin, and irinotecan. It is an anti-VEGF biologic therapy or, in the case of RAS wild-type, an anti-EGFR therapy. It is also indicated for the treatment of metastatic gastric or gastroesophageal junction adenocarcinoma in patients who have received at least two prior chemotherapy regimens including fluoropyrimidine, platinum, taxane, or irinotecan, and, if appropriate, HER2/NEU targeted therapy.

The original drug of trifluridine and tipiracil is sold in China as trifluridine and tipiracil tablets (Lonsurf), but it has not yet entered the scope of medical insurance. The common specifications are 15mg*20 tablets and 20mg*20 tablets. The price per box may be around 6,000 yuan. The price of the Hong Kong version of the original drug may be more than 10,000 yuan per box (the price may fluctuate due to exchange rates). At presentthe domestic generic version of trifluridine and tipiracil has been included in medical insurance, and the price may be around around 2,000 yuan.

The Japanese version of trifluridinetipiracil original drug, specification20 mg*20 tablets per box sold overseas may cost more than 5,000 yuan (the price may fluctuate due to exchange rates). There are also cheaper generic versions of trifluridine tipiracil tablets available for sale overseas. Their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of each box produced by an Indian pharmaceutical factory may be more than more than 1,000 yuan (the price may fluctuate due to exchange rates).