Detailed explanation of the monthly dosage and cost of trifluridine and tipiracil (Langsif)

Trifluridine and tipiracil (Lonsurf) are a treatment option for patients with colorectal and metastatic gastric cancer, particularly those who have experienced or are unable to receive conventional cancer therapies. This drug can be used in combination with bevacizumab to fight colorectal cancer. It comes in tablet form and contains the precise ingredients of trifluridine and tipiracil.

Each patient's dose of trifluridine and tipiracil is unique and customized based on the patient's body surface area, severity of illness, and overall health. Generally, the recommended dose is 35 mg/m² to a maximum of 80 mg of the trifluridine component twice daily. This treatment was continued on days 1 to 5 and 8 to 12 of each 28-day cycle. However, this is only a guideline dosage range, and the specific dosage should be accurately adjusted by the physician based on the patient's specific conditions.

When it comes to the cost of trifluridine and tipiracil, the original drug has a higher price on the market and is not currently covered by medical insurance, so patients need to bear the full cost. The price of the drug may fluctuate depending on the version and source. For example, the price of each box of the domestically marketed original drug may be as high as RMB 6,000, while the Hong Kong version may be more than 10,000 RMB. In addition, Japanese original drugs are also sold in overseas markets, and the price is about 5,000 yuan. These prices may be affected by exchange rate fluctuations.

For patients looking for a more economical option, generic versions of trifluridine and tipiracil are also available in overseas markets. These generic drugs are basically the same as the original drugs in terms of ingredients, but are more affordable. For example, the price of each box of generic drugs produced by Indian pharmaceutical factories may be around more than 1,000 yuan.