How much does neratinib/neratinib treatment cost for one year in 2024

Neratinib is a potent HER2 tyrosine kinase inhibitor (TKI) with high anticancer activity that also targets EGFR, which causes toxicity. Not only is it licensed for adjuvant treatment of breast cancer, it may also play a role in reducing brain recurrence, leading to better treatment options and promising survival benefits for patients with breast cancer with brain metastases. In addition, the combination of neratinib and fulvestrant has also shown efficacy against HER2-mutated breast cancer.

This medicine is availableas 40 mg tablets. The dose of neratinib for adjuvant treatment of early breast cancer is 240 mg once a day, which is equivalent to 6 tablets, each tablet containing 40 mg of neratinib. Take it with food, preferably in the morning, and the recommended total course of treatment is one year. Treatment with neratinib also needs to be started within one year after completion of trastuzumab therapy. The dose of neratinib for advanced or metastatic breast cancer is also 240mg (6 tablets), usually taken orally once daily with food on days 1-21 of a 21-day cycle. The specification of neratinib currently on the market is 40mg*180 tablets per box. One box of the drug can be used by patients for about one month. If the patient uses it for one year, a rough estimate is about 12 boxes.

The original drug Neratinib currently on the market in China and covered by medical insurance may cost around 7,000 RMB per box, so the price for a patient to use it for one year may be more than 100,000 RMB, which is even more expensive. Generic drugs of neratinib are also sold overseas, and their drug ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of each box produced by Bangladesh Yaopin International may be around more than 2,000 yuan (the price may fluctuate due to exchange rates). The price for a patient's use for one year may be tens of thousands of yuan, which is relatively cheap.