What is the latest price of entrectinib in 2024?

Entrectinib is an oral targeted therapy drug that is a receptor tyrosine kinase (RTK) inhibitor and is used to treat some specific types of cancer, especially those carrying neuronal tumor TRK gene fusion (NTRK) patients. It is also used to treat ROS1positive non-small cell lung cancer (NSCLC) and METamplified non-small cell lung cancer.

Entrectinib has been launched in China and has been included in medical insurance. Patients can buy it domestically, but the price is very high, about more than 20,000 yuan. For specific prices and medical insurance reimbursement, please consult the local hospital pharmacy. The cheaper ones abroad are entrectinib generics, mainly Laos generics. The price is about one to two thousand yuan, and the ingredients of the original drug and the generic are basically the same.

The mechanism of action of entrectinib involves effects on multiple targets, including TRKA, TRKB, TRKC, ROS1 and ALK, etc. These targets play key roles in the development and progression of some cancers. NTRK gene fusions have been found in a variety of malignancies, including solid tumors in children and adults, while abnormalities in ROS1 and ALK are common in NSCLC.

The development and use of this drug provides a new treatment option for some patients, especially those for whom traditional treatment options are limited or ineffective. Clinical trials have shown that entrectinib is well tolerated and effective in some patients, and for some patients with advanced cancer, it may be an important drug to extend survival time and improve quality of life.

While entrectinib offers hope to some cancer patients, it comes with some side effects and limitations. Common side effects include fatigue, nausea, vomiting, diarrhea, loss of appetite and other gastrointestinal reactions, as well as headache, weight gain, visual impairment, etc. Additionally, in pregnant women, entrectinib may cause harm to the fetus and should be avoided during pregnancy.