How much does a box of entrectinib cost in 2024?

Entrectinib is an oral, targeted inhibitor designed to treat specific types of cancer, mainly non-small cell lung cancer (NSCLC), breast cancer and other solid tumors. Its mechanism of action involves inhibiting certain protein kinases, such as ROS1, ALK, and TRK, which play key roles in some cancers.

Entrectinib is now on the market in China and has been successfully included in the medical insurance system. Domestic patients can purchase it directly. However, its price is quite expensive, with a cost of about 20,000 yuan. For detailed information on specific prices and medical insurance reimbursement, please consult the pharmacy staff of your local hospital. It is worth mentioning that there are some relatively low-priced entrectinib generic drugs on the foreign market, especially Laos generic drugs, which sell for about one to two thousand yuan. And after comparison, these generic drugs are basically consistent with the original drug in terms of drug ingredients.

Enrectinib has a significant effect on ROS1 fusion gene-positive tumors. ROS1The fusion gene is a cancer driver gene that has been found in various cancers such as lung cancer. Entrectinib can inhibit the activity of ROS1 protein kinase, thereby blocking the growth and spread of tumor cells.

For ALKpositiveNSCLC patients, entrectinib also showed excellent anti-tumor activity. ALKfusion gene is another common cancer driver gene and is particularly important in NSCLC. Entrectinib works by inhibiting the activity of ALK protein kinase, thereby inhibiting the proliferation and survival of tumor cells.

Enrectinib also exhibits activity againstTRK fusion genes. TRKGene fusion is a rare but important cancer-driving mechanism that is present in a variety of tumors. Entrectinib can block the promotion of tumor growth by these fusion genes by inhibiting the activity of TRK protein kinase.