How long should I take obeticholic acid?

Obeticholic acid (Obeticholic acid) is the first agonist that selectively binds to FXR. Obeticholic acid directly and indirectly inhibits bile acid production in the liver and increases bile flow, thereby reducing the liver's exposure to toxic levels of bile acids. These effects should clinically reduce substantial liver damage caused by bile acids, thereby improving biochemical enzyme profiles and slowing the progression of primary biliary cholangitis (PBC).

Obeeticholic acid is an oral drug with multiple daily dosesIt is rapidly absorbed and reaches peak plasma concentration 1.5 hours after administration of 10 mg. This medication is not affected by food. The average distribution volume of obeticholic acid and its conjugates is 618L, and the plasma protein binding rate is approximately 99%. Currently, the effect of other highly protein-bound drugs on the pharmacokinetic characteristics of obeticholic acid is unknown. After ingestion, obeticholic acid is extensively metabolized by the liver via conjugation to glycine and taurine. Once the conjugates are secreted into the bile and absorbed in the small intestine, they enter the enterohepatic circulation, where intestinal microbes deconjugate the metabolites and form obeticholic acid, which is then reabsorbed or excreted in the feces.

The duration of obeticholic acid use varies based on individual differences and disease conditions. Obeticholic acid is recommended as first-line treatment for patients with primary biliary cholangitis. According to the recommendations of clinical guidelines, patients generally need to take obeticholic acid for a long time. The goals of treatment are to maintain stable liver function, improve cholestasis, and slow disease progression. The specific medication time should be determined according to the doctor's guidance and the patient's specific condition. Continue taking obeticholic acid even if you feel well, and do not stop taking obeticholic acid without talking to your doctor.