There are several versions of obeticholic acid

The original manufacturer of Obeticholic acid (Obeticholic acid) is Intercept Pharmaceuticals, Inc. There are also some different brands and trade names, such as OCALIVA. These brands and trade names may be manufactured by different pharmaceutical companies and sold in different countries and regions. Regarding the generic manufacturers of obeticholic acid, their generic drugs are produced in many regions. Common generic drug manufacturers include ASEAN Pharmaceuticals in Laos, Beacon Pharmaceuticals in Bangladesh, Mylan Pharmaceuticals in India, etc. And the pharmaceutical ingredients of generic drugs are basically the same as those of the original drugs. Common specifications may be 5mg*30 tablets or 10mg*30 tablets per box.

Obeeticholic acid received accelerated approval from the U.S. Food and Drug Administration (FDA) in 2016 and is suitable for the treatment of patients with In adult patients with primary cholangitis (PBC) but no cirrhosis or compensated cirrhosis and no evidence of portal hypertension, it can be used in combination with ursodeoxycholic acid (UDCA), where UDCA is not effective, or as monotherapy in patients who cannot tolerate UDCA. Obeticholic acid indirectly reduces bile acid synthesis by acting on FXRs in ileal enterocytes to induce the release of FGF-19, which enters the portal circulation and binds to FGFR-4. The expression of the CYP7A1 gene is inhibited, resulting in reduced bile acid synthesis. In the liver, obeticholic acid directly stimulates BSEP to downregulate bile acid uptake in the portal circulation.

Obeticholic acid has not yet been approved for marketing in China, so it is not included in medical insurance and its price is not available. The price of each box of original drugs sold overseas may be more than 9,000 US dollars; the price of each box of generic drugs ranges from a few hundred to 1,000 yuan (prices may fluctuate due to exchange rates). For more drug information and specific prices, please consult Yaode Medical Consultant.