Ibrutinib/ibrutinib medical insurance price in 2024

In the domestic market, the original drug of ibrutinib/Ibrutinib is available in the form of capsule preparations and has been successfully included in the reimbursement scope of Class B medical insurance, but reimbursement is limited to patients who meet specific indications. Its common specifications are 140mg*90 capsules, and the price is about 10,000 yuan. Due to different reimbursement ratios in different regions, the price after reimbursement may be slightly different. For specific information, patients can consult the local medical insurance bureau or hospital.

Indications for patients currently eligible for medical insurance reimbursement in China include but are not limited to Treatment of patients with mantle cell lymphoma(MCL) who have received at least one treatment in the past; or Treatment of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL); or treatment of patients with Waldenstrom's macroglobulinemia (WM). When these patients are treated with ibrutinib, they need to follow the instructions of the doctor and follow the instructions for use and dosage.

Ibrutinib is a small molecule drug that inhibits B cell proliferation and survival by irreversibly binding to the protein Bruton's tyrosine kinase (BTK). Blocking BTK inhibits the B-cell receptor pathway, which is often hyperactive in B-cell cancers. Therefore, ibrutinib is used to treat this type of cancer. Ibrutinib also binds to the C-terminal Src kinase. These are non-target receptors for BTK inhibitors. Ibrutinib binds to these receptors and inhibits the kinases promoting cell differentiation and growth. During treatment for chronic lymphocytic leukemia, this can lead to many different side effects, such as left atrial enlargement and atrial fibrillation.

However, if a patient is taking ibrutinib while also taking other drugs that may interact with it or cause serious side effects, doctors may adjust the dose based on the specific situation or even interrupt treatment in some cases to ensure the patient's safety.