Vigabatrin (vigabatrin) oral solution powder detailed dosage instructions

1. Indications

Vigabatrin (Vigabatrin) solution is indicated for the treatment of refractory complex partial seizures.

2. Mechanism of action

Vigabatrin (vigabatrin) prevents the degradation of GABA by inhibiting the activity of GABA transaminase, and increases the concentration of GABA between neurons. This can enhance the inhibitory effect of GABA, thereby reducing the excitability of neurons and achieving anti-epileptic effects.

3. Pharmacology

Vigabatrin (vigabatrin) is mainly excreted by the kidneys in the body, and its bioavailability is as high as100%. After oral administration, it can be rapidly absorbed, and it takes about 1-2 hours to reach the highest blood concentration. Drugs are mainly metabolized in the body and excreted in the urine in the form of prototypes and metabolites.

4. Dosage and usage

4.1Adult dosage and usage

Starting dose: 1000mg daily (500mg twice daily).

Gradually incremental dosage: Increase 500mg weekly until you reach the recommended dose of 3000mg daily (1500mg twice daily).

4.2Dosage and usage in pediatric patients

10-15kg: Starting dose: 350mg daily (takentwice daily). Maintenance dose: 1050 mg daily.

15-20kg: Starting dose: 450mg daily (takentwice daily). Maintenance dose: 1300 mg daily.

20-25kg: Starting dose: 500mg daily (takentwice daily). Maintenance dose: 1500 mg daily.

25-60kg: Starting dose: 500mg daily (takentwice daily). Maintenance dose: 2000mg daily.

Over60kg: Take according to the adult dosage.

4.3Dosage and usage for patients with infantile spasms

Starting dose: Daily dose of 50 mg/kg (25 mg/kg twice daily).

Gradually increase dose: Increase total daily dose in increments of 25mg/kg/ days every 3 days until daily < Maximum daily dose of /span>150mg/kg (75mg twice daily).

5. Side Effects

5.1 Common side effects include dizziness, drowsiness, indigestion, headache and dry mouth.

5.2 Less common but serious side effects include retinopathy, psychiatric symptoms, blood abnormalities, allergic reactions, and abnormal liver function.

6. Warnings and Precautions

6.1 When using Vigabatrin (vigabatrin) the retinal condition should be checked regularly to monitor for retinopathy.

6.2 Liver function, blood tests and other possible adverse reactions should be monitored regularly during the use of Vigabatrin (vigabatrin).

6.3 Vigabatrin (vigabatrin) should be used with cautionfor patients with pre-existing retinopathy, mental illness, liver dysfunction, etc.

7. Contraindications

It is contraindicated in patients allergic tovigabatrin (vigabatrin).

Use is contraindicated in patients with known retinopathy, psychiatric illness, or severe hepatic impairment.

8. Drug interactions

8.1 Vigabatrin (vigabatrin) may interact with other anti-epileptic drugs, resulting in increased or decreased efficacy.

8.2 Coadministration with other CNS depressants (such as alcohol) may increase the risk of drowsiness and other CNS side effects.

9. Listing and Price

Vigabatrin (vigabatrin) It has been marketed in China and has been included in medical insurance. Patients can buy it domestically, but the price is relatively high. The price of a 500mg*30 bag is about 2,000 yuan. Please consult the local hospital pharmacy for specific prices and medical insurance reimbursement information. At present, the cheaper original drugs are mainly original drugs from Hong Kong, China. The price of 500mg*100bags is more than 1,000 yuan, and the efficacy is the same as the domestic Vigabatrin (vigabatrin) .

The above is the detailed medication instructions for Vigabatrin (vigabatrin) oral solution. Patients should follow the doctor's advice when using the drug and pay close attention to the dosage and usage of the drug.