Lorlatinib/Lorlatinib What medicine should you take for high blood pressure?

Hypertension may occur in patients receiving lorlatinib/lorlatinib (Lolatinib). In clinical studies, 13% of patients taking 100 mg of lorlatinib once daily developed hypertension, with 6% of patients developing grade 3 or 4 hypertension. The median time to onset of hypertension was 6.4 months, and 2.3% of patients temporarily discontinued lorlatinib due to hypertension. Doctors will advise patients to control their blood pressure before starting lorlatinib. Monitor blood pressure after 2 weeks of treatment with lorlatinib and at least monthly thereafter.

After evaluating the patient's specific situation, the doctor may decide whether specific medications are needed to control blood pressure based on the patient's blood pressure level and physical condition. The following are some common medication options, but specific treatment decisions should be made by the doctor based on the patient's specific situation:

1. Calcium channel blockers: These drugs can lower blood pressure by dilating blood vessels and reducing cardiac contractility and heart rate. Common calcium channel blockers include amlodipine (Amlodipine), nifedipine (Nifedipine), etc.

2. Diuretics: Diuretics can increase urine excretion, reduce salt and water retention in the body, and thereby lower blood pressure. Common diuretics include loop diuretics such as furosemide, thiazide diuretics such as hydrochlorothiazide, etc.

In summary, lorlatinib is an effective drug for ALK fusion gene-positive non-small cell lung cancer. It has anti-tumor effects and can be used to treat recurrent or metastatic lung cancer, and has shown good safety and tolerability clinically. Medication therapy should be determined by a physician based on the patient's specific circumstances and requires regular follow-up and adjustments. In addition, patients should follow their doctor's instructions, use medications correctly, and promptly report any discomfort or side effects to their doctor.