How to purchase Enfortumab and where to buy it

Enfortumab is a new targeted anti-cancer drug used to treat advanced urothelial cancer (urothelial cancer), a malignant tumor affecting the urinary system. The drug was approved by the U.S. Food and Drug Administration (FDA) in 2019 and has become a new first-line treatment option for advanced urothelial cancer.

Ennosumab has not yet been launched in the domestic market, so domestic patients cannot purchase it directly. To obtain this drug, patients must purchase it from overseas. Currently, all ennosumab available in overseas markets are original drugs, mainly Japanese original drugs. However, their prices are high, with a single purchase cost exceeding RMB 10,000.

Ennosumab belongs to a class of drugs called antibody-drug conjugates (antibody-drug conjugate,ADC). It consists of a synthetic antibody and a toxic drug that targets cancer cells. This antibody selectively binds to a specific protein on the surface of urothelial cancer cells, called Nectin-4. Once ennosumab binds to cancer cells, it releases toxic drugs that directly attack and kill cancer cells, thereby inhibiting tumor growth and spread.

Advanced urothelial cancer is often a refractory disease that is often resistant to traditional treatment modalities such as chemotherapy or immunotherapy. However, as a targeted drug, ennosumab has a more precise mechanism of action and can attack tumor cells more effectively, thus bringing new treatment options to patients with advanced urothelial cancer.

Clinical trials have shown that ennosumab exhibits good efficacy and safety in the treatment of patients with advanced urothelial cancer. Many patients show tumor shrinkage or stabilization after treatment with ennosumab, extending survival and quality of life.

Although ennosumab has made significant progress in the treatment of advanced urothelial cancer, there are still some side effects, including nausea, fatigue, hair loss, etc. Therefore, before using ennozumab, doctors will evaluate the patient's overall health status and develop the most appropriate treatment plan based on the individual situation.