How much does acalatinib cost per month?

Acalabrutinib/Acalabrutinib is a selective inhibitor of BTK. Acotinib covalently binds to BTK, thereby inhibiting its activity, and has demonstrated this in preclinical studies with minimal interactions with other immune cells. In B cells, BTK signaling leads to the activation of pathways necessary for B cell proliferation, trafficking, chemotaxis, and adhesion. Acotinib is also in development for the treatment of a variety of B-cell malignancies and other cancers, including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and others.

The recommended dose of acotinib is one 100 mg capsule taken orally approximately every 12 hours until disease progression or unacceptable toxicity occurs. Acotinib can be taken with or without food. Regarding the specifications and doses of acotinib, the common specifications listed in China are 100mg*8 tablets and 7 plates, while overseas there are packages of 100mg*60 tablets. Based on these specifications, you can roughly estimate that it will take approximately one month (30 days) for a patient to take one box of acotinib.

Acotinib, which is marketed in China, is covered by medical insurance. Each box costs about 40,000 yuan, and a patient needs one box for a month. In overseas markets, the price of this original drug is as high as more than 10,000 US dollars, which is obviously prohibitively expensive. The good news is that generic drugs of acotinib are already on the market, and their ingredients are basically the same as the original drug. For example, each box produced by a pharmaceutical company in Laos may cost more than 3,000 RMB (the price may fluctuate due to exchange rate changes), and the price for a patient's use for one month may be less than 5,000 RMB, which is much cheaper than the original product.